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Anaerobes in cystic fibrosis patients' airways.
- Source :
-
Critical reviews in microbiology [Crit Rev Microbiol] 2019 Feb; Vol. 45 (1), pp. 103-117. Date of Electronic Publication: 2019 Jan 21. - Publication Year :
- 2019
-
Abstract
- Anaerobes are known to constitute an important part of the airway microbiota in both healthy subjects and cystic fibrosis (CF) patients. Studies on the potential role of anaerobic bacteria in CF and thus their involvement in CF pathophysiology have reported contradictory results, and the question is still not elucidated. The aim of this study was to summarize anaerobe diversity in the airway microbiota and its potential role in CF, to provide an overview of the state of knowledge on anaerobe antibiotic resistances (resistome), and to investigate the detectable metabolites produced by anaerobes in CF airways (metabolome). This review emphasizes key metabolites produced by strict anaerobic bacteria (sphingolipids, fermentation-induced metabolites and metabolites involved in quorum-sensing), which may be essential for the better understanding of lung disease pathophysiology in CF.
- Subjects :
- Bacteria, Anaerobic chemistry
Bacteria, Anaerobic isolation & purification
Bacterial Infections complications
Drug Resistance, Bacterial
Humans
Metabolome
Respiratory Tract Infections complications
Bacteria, Anaerobic classification
Bacteria, Anaerobic growth & development
Biodiversity
Cystic Fibrosis microbiology
Cystic Fibrosis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1549-7828
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Critical reviews in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 30663924
- Full Text :
- https://doi.org/10.1080/1040841X.2018.1549019