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Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A challenging question for gynecologic oncologists.
- Source :
-
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2019 Jan; Vol. 133, pp. 92-98. Date of Electronic Publication: 2018 Nov 02. - Publication Year :
- 2019
-
Abstract
- Mature cystic teratomas of the ovary have an incidence of 1.2-14.2 cases per 100.000 people per year. Malignant transformation occurs in approximately 2% of the cases, and usually consists of squamous cell carcinoma. The preoperative detection is difficult and the diagnostic accuracy of ultrasound, magnetic resonance imaging, and computed tomography is debated. The diagnosis is frequently made in the operating room or on final histological examination. Standard treatment consists of bilateral salpingo-oophorectomy, total hysterectomy and comprehensive surgical staging in early disease and optimal cytoreductive surgery in advanced disease. Paclitaxel/carboplatin- based chemotherapy is the most used adjuvant treatment, whereas more aggressive regimens can be adopted in patients with high tumor burden or recurrent disease. The efficacy of radiotherapy is still unproven. The prognosis is poor when the tumor has spread beyond the ovary. There are few information to provide commonly accepted guidelines for this malignancy.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Carcinoma, Squamous Cell diagnosis
Carcinoma, Squamous Cell therapy
Cell Transformation, Neoplastic pathology
Diagnosis, Differential
Disease Progression
Female
Humans
Medical Oncology methods
Neoplasm Staging
Ovarian Cysts therapy
Ovarian Neoplasms diagnosis
Ovarian Neoplasms therapy
Teratoma diagnosis
Teratoma therapy
Carcinoma, Squamous Cell pathology
Diagnostic Techniques, Obstetrical and Gynecological
Ovarian Cysts diagnosis
Ovarian Cysts pathology
Ovarian Neoplasms pathology
Teratoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0461
- Volume :
- 133
- Database :
- MEDLINE
- Journal :
- Critical reviews in oncology/hematology
- Publication Type :
- Academic Journal
- Accession number :
- 30661663
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2018.10.005