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Seven new neuroprotective sesquineolignans isolated from the seeds of Crataegus pinnatifida.
- Source :
-
Fitoterapia [Fitoterapia] 2019 Mar; Vol. 133, pp. 225-230. Date of Electronic Publication: 2019 Jan 17. - Publication Year :
- 2019
-
Abstract
- The investigation of the ethanol extract of the seeds of Crataegus pinnatifida led to the isolation of seven new 8-O-4' type sesquineolignans crasesquineolignan A-G (1-7), along with a reported analogue, leptolepisol B (8). The chemical structures of these compounds were elucidated based on complex analysis of their MS, 1D and 2D NMR data. All the isolated compounds were tested for their neuroprotective effects against the damage of human neuroblastoma SH-SY5Y cells induced by H <subscript>2</subscript> O <subscript>2</subscript> , and most of them showed significant neuroprotective activity. Among them, compound 4 (77.58%) showed the best protective effect, even better than the positive control (69.26%) at 25 μM.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Cell Line, Tumor
Humans
Hydrogen Peroxide
Lignans isolation & purification
Neuroblastoma drug therapy
Neuroprotective Agents isolation & purification
Phytochemicals isolation & purification
Phytochemicals pharmacology
Plant Extracts chemistry
Crataegus chemistry
Lignans pharmacology
Neuroprotective Agents pharmacology
Seeds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 133
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 30660653
- Full Text :
- https://doi.org/10.1016/j.fitote.2019.01.008