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Early Motor-Behavioral Outcome of Ischemic Stroke with Ketogenic Diet Preconditioning: Interventional Animal Study.
- Source :
-
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2019 Apr; Vol. 28 (4), pp. 1032-1039. Date of Electronic Publication: 2019 Jan 16. - Publication Year :
- 2019
-
Abstract
- Background: Cerebral stroke, with ischemic stroke being its most common type, is the leading cause of chronic disability. The ketogenic diet has been used for treating seizures for centuries and has been considered to be a treatment for other neurologic diseases in recent years. The goal of this study is to evaluate the effects of ketogenic diet preconditioning on the early motor-behavior outcome of rats with induced cerebral ischemic stroke.<br />Methods: Twenty-four rats were surveyed in 3 groups of Main, Control, and Sham. The Main group received a ketogenic diet plus medium chain triglyceride oil starting 3 days prior to stroke induction, while the other 2 groups took a normal diet. Subsequently, Endothelin-1 was injected stereotactically near the middle cerebral artery to induce an ischemic stroke in the Main and Control group. Normal saline was injected to the members of the Sham group with the same technique. The motor-behavior functions of the rats were compared between 3 groups using adjusting step, beam, and cylinder tests.<br />Results: After stroke induction, rats on ketogenic diet were able to adjust their steps more efficiently, moved faster on the beam, and used their hands more symmetrically in the transparent cylinder in relation to the rats in the Control group.<br />Conclusion: It seems that ketogenic diet preconditioning improves the early motor-behavioral outcome of ischemic stroke.<br /> (Copyright © 2019. Published by Elsevier Inc.)
- Subjects :
- Animals
Brain Ischemia diagnosis
Brain Ischemia physiopathology
Brain Ischemia psychology
Disease Models, Animal
Infarction, Middle Cerebral Artery diagnosis
Infarction, Middle Cerebral Artery physiopathology
Infarction, Middle Cerebral Artery psychology
Male
Rats, Wistar
Time Factors
Behavior, Animal
Brain Ischemia diet therapy
Diet, Ketogenic
Infarction, Middle Cerebral Artery diet therapy
Motor Activity
Physical Conditioning, Animal methods
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8511
- Volume :
- 28
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Publication Type :
- Academic Journal
- Accession number :
- 30658953
- Full Text :
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.024