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Impact of the direct-acting antiviral agents (DAAs) on chronic hepatitis C in Sardinian patients with transfusion-dependent Thalassemia major.
- Source :
-
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2019 Apr; Vol. 51 (4), pp. 561-567. Date of Electronic Publication: 2019 Jan 03. - Publication Year :
- 2019
-
Abstract
- Background and Aims: Direct antiviral agents (DAAs) have revolutionised the standard of care for the treatment of hepatitis even in patients with hemoglobinopathies. The aim of this study is to show how, thanks to DAAs, HCV infection has been substantially eradicated in one of the biggest Centres for the management of Thalassemia in Europe.<br />Methods: Thalassemia major patients regularly transfused and iron chelated in Cagliari (Italy) who were HCV-RNA positive were evaluated for the potential prescription of antiviral therapy.<br />Results: A total of 99 patients, 26 of whom had been diagnosed with cirrhosis, were treated with at least one dose of DAAs, which proved to be safe and well tolerated. Two of the patients died during the treatment after becoming HCV-RNA negative while another voluntarily interrupted the therapy. The final SVR in the patients who completed the treatment was 100%, while measuring 97% (96/99) in the Intention-to-Treat analysis. After DAAs, no new cases of hepatocellular carcinoma have been reported.<br />Conclusions: The use of DAAs in patients suffering from beta-Thalassemia major with chronic hepatitis C or cirrhosis can be considered safe and effective. Close monitoring for hepatocellular carcinoma development is, in any case, recommended indefinitely post-SVR.<br /> (Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Antiviral Agents adverse effects
Female
Hepacivirus drug effects
Hepatitis C, Chronic complications
Humans
Italy
Liver Cirrhosis virology
Male
Middle Aged
Sustained Virologic Response
Antiviral Agents therapeutic use
Hepacivirus genetics
Hepatitis C, Chronic drug therapy
Liver Cirrhosis etiology
beta-Thalassemia complications
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3562
- Volume :
- 51
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 30658940
- Full Text :
- https://doi.org/10.1016/j.dld.2018.12.016