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Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2019 Jan 17; Vol. 24 (2). Date of Electronic Publication: 2019 Jan 17. - Publication Year :
- 2019
-
Abstract
- Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A⁻E ( 1 ⁻ 5 ) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1 ⁻ 5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC <subscript>50</subscript> ranging from 5.9 to 33.9 μM compared to Cisplatin.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 30658485
- Full Text :
- https://doi.org/10.3390/molecules24020331