Back to Search
Start Over
Microbes and Alzheimer' disease: lessons from H. pylori and GUT microbiota.
- Source :
-
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2019 Jan; Vol. 23 (1), pp. 426-430. - Publication Year :
- 2019
-
Abstract
- Objective: the role of microbes and chronic inflammation in the pathogenesis of Alzheimer' disease (AD) has been postulated by many authors. On the other hand, several studies have reported the main role of H. pylori infection and/or GUT microbiota alteration in promoting chronic inflammation, thus possibly influencing both occurrence and evolution of AD. In this article, we analyze the most important and recent studies performed on this field both on humans and animals and provide possible pathogenic explanations.<br />Results: all main and most recent animal, human, epidemiological and in-silico studies, showed a role of H. pylori and/or dysbiosis in AD, mostly through the promotion of systemic chronic inflammation and/or by triggering molecular mimicry mechanisms. In particular, H. pylori infection seems to be related to a poorer cognitive performance.<br />Conclusions: Indeed, bacteria have been shown to affect neurodegeneration by promoting inflammation, inducing molecular mimicry mechanisms and accumulation of Aβ into the brain. These findings open the way for H. pylori eradicating trials and/or GUT microbiota remodulating strategies. Therefore, further studies are now needed in order to test whether antibiotics, pre and/or probiotics may exert a beneficial effect in the prevention of AD.
- Subjects :
- Alzheimer Disease microbiology
Alzheimer Disease pathology
Alzheimer Disease prevention & control
Amyloid beta-Peptides immunology
Amyloid beta-Peptides metabolism
Animals
Anti-Bacterial Agents administration & dosage
Brain immunology
Cognition
Disease Models, Animal
Dysbiosis complications
Dysbiosis drug therapy
Dysbiosis microbiology
Gastrointestinal Microbiome drug effects
Helicobacter Infections complications
Helicobacter Infections drug therapy
Helicobacter Infections microbiology
Helicobacter pylori immunology
Helicobacter pylori isolation & purification
Humans
Molecular Mimicry immunology
Probiotics administration & dosage
Alzheimer Disease immunology
Brain pathology
Dysbiosis immunology
Gastrointestinal Microbiome immunology
Helicobacter Infections immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2284-0729
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European review for medical and pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30657587
- Full Text :
- https://doi.org/10.26355/eurrev_201901_16791