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Stress hormones modulate lipopolysaccharide stimulation of head kidney interleukin-6 production in the catfish Heteropneustes fossilis: In vivo and in vitro studies.
- Source :
-
General and comparative endocrinology [Gen Comp Endocrinol] 2019 Aug 01; Vol. 279, pp. 109-113. Date of Electronic Publication: 2019 Jan 14. - Publication Year :
- 2019
-
Abstract
- Interleukin-6 (IL-6) is a pleiotropic cytokine secreted by immune tissues such as monocytes/macrophages and have pro-inflammatory/anti-inflammatory and neuroendocrine actions. In this study, we report the modulatory effects of stress hormones, the cortisol agonist dexamethasone and catecholamines on lipopolysaccharide (LPS) - induced stimulation of head kidney IL-6 in the catfish Heteropneustes fossilis. In the in vivo study, the intraperitoneal administration of LPS stimulated, and dexamethasone time-dependently inhibited IL-6 level. In the in vitro study, the incubation of macrophage cultures with LPS stimulated IL-6 level significantly in all incubation times. Dexamethasone did not alter the basal IL-6 level but inhibited time-dependently the LPS-induced stimulation. Likewise, catecholamines did not alter the basal level of IL-6. Both epinephrine and norepinephrine inhibited the LPS-induced stimulation of IL-6. Dopamine, on the other hand, was ineffective. The results indicate that IL-6 is a useful marker of head kidney macrophage activity for studying endocrine-immune interactions in the catfish.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Dexamethasone pharmacology
Epinephrine pharmacology
Head Kidney drug effects
Hydrocortisone pharmacology
Norepinephrine pharmacology
Catecholamines pharmacology
Catfishes metabolism
Head Kidney metabolism
Interleukin-6 biosynthesis
Lipopolysaccharides pharmacology
Stress, Physiological
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6840
- Volume :
- 279
- Database :
- MEDLINE
- Journal :
- General and comparative endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 30654022
- Full Text :
- https://doi.org/10.1016/j.ygcen.2019.01.005