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Aprepitant in Anti-histamine-refractory Chronic Nodular Prurigo: A Multicentre, Randomized, Double-blind, Placebo-controlled, Cross-over, Phase-II trial (APREPRU).
- Source :
-
Acta dermato-venereologica [Acta Derm Venereol] 2019 Apr 01; Vol. 99 (4), pp. 379-385. - Publication Year :
- 2019
-
Abstract
- The aim of this multicentre, randomized, double-blind, placebo-controlled, cross-over, phase-II study was to determine the antipruritic effect of aprepitant vs. placebo in 58 patients with anti-histamine-refractory chronic pruritus in chronic nodular prurigo. Patients were randomized to receive either first oral aprepitant 80 mg/day or placebo for 4 weeks. Following a 2-week wash-out phase, the patients were crossed-over to receive the other treatment for 4 weeks. Primary efficacy criterion was the intra-individual difference between mean itch intensity (visual analogue scale) at baseline compared with the end of treatment period. Prurigo lesions, pruritus course, quality of life, patient benefits, and safety were secondary parameters. No significant differences were found between aprepitant treatment and placebo for any of the parameters investigated. Under the experimental conditions of the study, aprepitant, 80 mg daily for 4 weeks, did not have an antipruritic effect in patients with chronic prurigo. (DRKS00005594; EudraCT Number: 2013-001601-85).
- Subjects :
- Adolescent
Adult
Aged
Antipruritics adverse effects
Aprepitant adverse effects
Cross-Over Studies
Double-Blind Method
Drug Resistance
Female
Germany
Humans
Male
Middle Aged
Neurokinin-1 Receptor Antagonists adverse effects
Prurigo diagnosis
Prurigo immunology
Quality of Life
Severity of Illness Index
Time Factors
Treatment Outcome
Young Adult
Antipruritics therapeutic use
Aprepitant therapeutic use
Histamine Antagonists therapeutic use
Neurokinin-1 Receptor Antagonists therapeutic use
Prurigo drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2057
- Volume :
- 99
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta dermato-venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 30653242
- Full Text :
- https://doi.org/10.2340/00015555-3120