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3D-ASL perfusion correlates with VEGF expression and overall survival in glioma patients: Comparison of quantitative perfusion and pathology on accurate spatial location-matched basis.
- Source :
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Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2019 Jul; Vol. 50 (1), pp. 209-220. Date of Electronic Publication: 2019 Jan 16. - Publication Year :
- 2019
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Abstract
- Background: There is a need for an imaging-based tool for measuring vascular endothelial growth factor (VEGF) expression and overall survival (OS) in patients with glioma.<br />Purpose: To assess the correlation between cerebral blood flow (CBF), measured by 3D pseudo-continuous arterial spin-labeling (3D-ASL), and VEGF expression in gliomas on the basis of coregistered localized biopsy, and investigate whether CBF correlated with survival month (SM) in glioma patients.<br />Study Type: Prospective cohort.<br />Subjects: Thirty-seven patients with gliomas from whom 63 biopsy specimens were obtained.<br />Sequence: 3D-ASL acquired with a 3.0T MR unit.<br />Assessment: Biopsy specimens were grouped as high-grade (HGG) or low-grade glioma (LGG). CBF measurements were spatially matched with VEGF expression by coregistered localized biopsies, and the CBF value was correlated with quantitative VEGF expression for each specimen. Patients' survival information was derived and connected with CBF.<br />Statistical Tests: Patients' OS was analyzed by Kaplan-Meier and Cox-regression methods. VEGF expression and CBF were compared in both LGG and HGG. The Spearman rank correlation was calculated for CBF and VEGF expression, SM. Significance level, P < 0.05.<br />Results: CBF-derived 3D-ASL positively correlated significantly with VEGF expression in both LGG (31 specimens) and HGG (32 specimens), r = 0.604 (P < 0.001) and r = 0.665 (P < 0.001), respectively. LGG and HGG together gave a correlation coefficient r = 0.728 (P < 0.001). Median survival for LGG and HGG patients was 34.19 and 17.17 months, respectively (P = 0.037); CBF value negatively correlated significantly with SM with r = -0.714 (P < 0.001) regardless of glioma grade. CBF was an independent risk factor for OS with HR = 1.027 (P = 0.044), 1.028 (P = 0.010) for univariate/multivariate regression analysis.<br />Data Conclusion: CBF determined by 3D-ASL correlates with VEGF expression in glioma and is an independent risk factor for OS in these patients.<br />Level of Evidence: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:209-220.<br /> (© 2019 International Society for Magnetic Resonance in Medicine.)
- Subjects :
- Adolescent
Adult
Aged
Brain Neoplasms mortality
Brain Neoplasms pathology
Cerebrovascular Circulation
Female
Glioma mortality
Glioma pathology
Humans
Image Processing, Computer-Assisted
Image-Guided Biopsy
Male
Middle Aged
Neoplasm Grading
Prospective Studies
Spin Labels
Survival Rate
Brain Neoplasms diagnostic imaging
Brain Neoplasms metabolism
Glioma diagnostic imaging
Glioma metabolism
Imaging, Three-Dimensional methods
Magnetic Resonance Imaging methods
Vascular Endothelial Growth Factor A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2586
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Publication Type :
- Academic Journal
- Accession number :
- 30652410
- Full Text :
- https://doi.org/10.1002/jmri.26562