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The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes.
- Source :
-
Head & neck [Head Neck] 2019 Jun; Vol. 41 (6), pp. 1830-1845. Date of Electronic Publication: 2019 Jan 16. - Publication Year :
- 2019
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Abstract
- Background: We aimed at identifying molecular markers predictive of clinical outcome in patients with head and neck cancer based on the expression profile of cells showing epithelial-like (EL) or mesenchymal-like (ML) phenotypes.<br />Materials and Methods: We analyzed the association between EL and ML cells and migration, drug resistance, or tumor growth. The differential gene expression profile between cell types was used to build a model to stratify patients according to survival.<br />Results: EL cells were sensitive to cisplatin and cetuximab, showed low migration, and generated squamous differentiated tumors in mouse. A differential 93-gene expression signature between ML and EL cells was used to build a three-gene (EFS, GPX2, and SPRR1A) survival model by analyzing the RNA-seq data of the TCGA-HNSC project. Its prognostic value was confirmed in two independent cohorts.<br />Conclusion: EFS, GPX2, and SPRR1A are prognostic markers able to distinguish clinical outcome among subtypes sharing an EL phenotype.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Adaptor Proteins, Signal Transducing metabolism
Animals
Antineoplastic Agents therapeutic use
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell metabolism
Cetuximab therapeutic use
Cisplatin therapeutic use
Cohort Studies
Cornified Envelope Proline-Rich Proteins metabolism
Disease Models, Animal
Epithelial-Mesenchymal Transition
Glutathione Peroxidase metabolism
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms metabolism
Humans
Mice
RNA, Messenger metabolism
Treatment Outcome
Adaptor Proteins, Signal Transducing genetics
Carcinoma, Squamous Cell genetics
Cornified Envelope Proline-Rich Proteins genetics
Glutathione Peroxidase genetics
Head and Neck Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 41
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 30652380
- Full Text :
- https://doi.org/10.1002/hed.25623