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Significance of the preoperative regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the future remnant liver: a sequential study of regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the whole liver.
- Source :
-
Nuclear medicine communications [Nucl Med Commun] 2019 Feb; Vol. 40 (2), pp. 145-152. - Publication Year :
- 2019
-
Abstract
- Background: The relationship between posthepatectomy complications and liver functional parameters was preliminary reported in a pilot study. The present study sequentially evaluated the clinical significance of maximal removal rate of technetium-99m-galactosyl human serum albumin (GSARmax) in the future remnant liver (rGSARmax) in patients to predict posthepatectomy complications.<br />Methods: Between 2010 and August 2017, GSARmax, rGSARmax, their difference (Dif), and the rGSARmax to GSARmax ratio were examined in 247 additional patients who underwent hepatectomy for liver and biliary diseases. Hepatectomy-related postoperative complications (i.e. long-term ascites, intra-abdominal infection, and hepatic failure) occurred in 73 (29.6%) patients.<br />Results: The median and mean preoperative GSARmax values were 0.477 and 0.498±0.166 mg/min, respectively; rGSARmax values were 0.341 and 0.366±0.145 mg/min, respectively; Dif values were 0.105 and 0.132±0.111 mg/min, respectively; and the rGSARmax to GSARmax ratio values were 0.774 and 0.746±0.177, respectively. Among these, the GSARmax and rGSARmax values were significantly correlated with the liver functional parameters ICGR15, LHL15, HH15, prothrombin activity, serum hyaluronic acid level, and platelet count (all P<0.01). The rGSARmax values were significantly lower in patients with long-term ascites (P<0.05), and the predictive cutoff values of rGSARmax were 0.290 mg/min; however, the multivariate logistic regression analysis showed that rGSARmax was not independently related to long-term ascites.<br />Conclusion: When accompanied by other functional liver reserve parameters, rGSARmax seemed to be an alternative liver functional parameter related to ascites.
- Subjects :
- Adult
Aged
Aged, 80 and over
Ascites diagnosis
Ascites etiology
Female
Humans
Liver diagnostic imaging
Liver physiopathology
Male
Middle Aged
Pilot Projects
Postoperative Complications diagnosis
Postoperative Complications etiology
Prognosis
Young Adult
Hepatectomy adverse effects
Liver metabolism
Liver surgery
Preoperative Period
Technetium Tc 99m Aggregated Albumin metabolism
Technetium Tc 99m Pentetate metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5628
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nuclear medicine communications
- Publication Type :
- Academic Journal
- Accession number :
- 30650068
- Full Text :
- https://doi.org/10.1097/MNM.0000000000000950