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Whole genome sequencing suggests transmission of Corynebacterium diphtheriae -caused cutaneous diphtheria in two siblings, Germany, 2018.
- Source :
-
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2019 Jan; Vol. 24 (2). - Publication Year :
- 2019
-
Abstract
- In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child's sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae . Next generation sequencing (NGS) revealed the same strain in both patients suggesting very recent human-to-human transmission. Epidemiological and NGS data suggest that the two cutaneous diphtheria cases constitute the first outbreak by toxigenic C. diphtheriae in Germany since the 1980s.
- Subjects :
- Amoxicillin therapeutic use
Anti-Bacterial Agents therapeutic use
Child
Clavulanic Acid therapeutic use
DNA, Bacterial isolation & purification
DNA, Bacterial metabolism
Diphtheria drug therapy
Diphtheria transmission
Female
Germany
Humans
Real-Time Polymerase Chain Reaction
Siblings
Somalia
Travel
Treatment Outcome
Whole Genome Sequencing
Corynebacterium diphtheriae genetics
Corynebacterium diphtheriae isolation & purification
Diphtheria diagnosis
Diphtheria Toxin genetics
High-Throughput Nucleotide Sequencing methods
Subjects
Details
- Language :
- English
- ISSN :
- 1560-7917
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 30646974
- Full Text :
- https://doi.org/10.2807/1560-7917.ES.2019.24.2.1800683