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Effect of preconceptional DHEA treatment on in vitro fertilization outcome in poor ovarian respond women: study protocol for a randomized controlled trial.
- Source :
-
Trials [Trials] 2019 Jan 15; Vol. 20 (1), pp. 50. Date of Electronic Publication: 2019 Jan 15. - Publication Year :
- 2019
-
Abstract
- Background: Women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with poor ovarian respond (POR) always have very low clinical pregnancy rates. In previous data, dehydroepiandrosterone (DHEA) was suggested as a promising treatment and maybe has a good pregnancy outcome. But there is no sufficient evidence from randomized clinical trials evaluating the effect of DHEA preconceptional treatment on live birth in POR.<br />Methods: This trial is a multicenter active-placebo double-blind clinical trial (1:1 treatment ratio of active versus placebo). The infertile POR patients undergoing IVF or ICSI will be enrolled and randomly assigned to two parallel groups. Participants in these two groups will be given 4-12 weeks' treatment of DHEA or placebo, respectively. The primary outcome is live birth rate.<br />Discussion: The results of this study will provide evidence for the effect of preconceptional DHEA treatment on IVF outcome in POR.<br />Trial Registration: Chinese Clinical Trial Registry, ChiCTR-IPR-15006909 . Registered on November 9, 2015.
- Subjects :
- Dehydroepiandrosterone adverse effects
Double-Blind Method
Embryo Culture Techniques
Embryo Transfer
Female
Fertility Agents, Female adverse effects
Humans
Infertility, Female diagnosis
Infertility, Female physiopathology
Live Birth
Multicenter Studies as Topic
Oocyte Retrieval
Ovary physiopathology
Ovulation Induction
Pregnancy
Pregnancy Rate
Prospective Studies
Randomized Controlled Trials as Topic
Sperm Injections, Intracytoplasmic
Time Factors
Treatment Outcome
Dehydroepiandrosterone administration & dosage
Fertility Agents, Female administration & dosage
Fertilization in Vitro
Infertility, Female therapy
Ovary drug effects
Ovulation drug effects
Preconception Care methods
Subjects
Details
- Language :
- English
- ISSN :
- 1745-6215
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Trials
- Publication Type :
- Academic Journal
- Accession number :
- 30646929
- Full Text :
- https://doi.org/10.1186/s13063-018-3146-x