Back to Search
Start Over
9-Norlignans: Occurrence, Properties and Their Semisynthetic Preparation from Hydroxymatairesinol.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2019 Jan 09; Vol. 24 (2). Date of Electronic Publication: 2019 Jan 09. - Publication Year :
- 2019
-
Abstract
- Lignans, neolignans, norlignans and norneolignans constitute a large class of phenolic natural compounds. 9-Norlignans, here defined to contain a β⁻β' bond between the two phenylpropanoid units and to lack carbon number 9 from the parent lignan structure, are the most rarely occurring compounds within this class of natural compounds. We present here an overview of the structure, occurrence and biological activity of thirty-five 9-norlignans reported in the literature to date. In addition, we report the semisynthetic preparation of sixteen 9-norlignans using the natural lignan hydroxymatairesinol obtained from spruce knots, as starting material. 9-Norlignans are shown to exist in different species and to have various biological activities, and they may therefore serve as lead compounds for example for the development of anticancer agents. Hydroxymatairesinol is shown to be a readily available starting material for the preparation of norlignans of the imperanene, vitrofolal and noralashinol family.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Proliferation drug effects
Cell Survival drug effects
HL-60 Cells
HeLa Cells
Humans
Lignans chemistry
Lignans pharmacology
Molecular Structure
Antineoplastic Agents chemical synthesis
Lignans chemical synthesis
Picea chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 30634427
- Full Text :
- https://doi.org/10.3390/molecules24020220