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Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy.
- Source :
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International ophthalmology [Int Ophthalmol] 2019 Oct; Vol. 39 (10), pp. 2237-2243. Date of Electronic Publication: 2019 Jan 09. - Publication Year :
- 2019
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Abstract
- Purpose: To study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR).<br />Methods: This is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c < 7, n = 26) and group 2 (HbA1c > 7, n = 37). Data were analyzed statistically.<br />Results: Mean ionic calcium levels in group 1 and group 2 were 1.131 ± 0.073 mmol/dL and 1.170 ± 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p = 0.01) in group 2 cases.<br />Conclusion: Increased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c > 7 in DR.
Details
- Language :
- English
- ISSN :
- 1573-2630
- Volume :
- 39
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- International ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 30628026
- Full Text :
- https://doi.org/10.1007/s10792-018-01063-8