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Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: A contemporary cohort study.
- Source :
-
Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2019 Feb; Vol. 28, pp. 235-243. Date of Electronic Publication: 2019 Jan 03. - Publication Year :
- 2019
-
Abstract
- Background: Exposure to disease-modifying therapy (DMT) during early pregnancy in women with relapsing-remitting MS (RRMS) may be increasing.<br />Objective: To retrospectively determine incidence of pregnancy, DMT exposure and pregnancy outcomes in women with RRMS.<br />Methods: We identified all women with RRMS aged 15-45 years in the MSBase Registry between 2005-2016. Annualised pregnancy incidence rates were calculated using Poisson regression models. DMT exposures and pregnancy outcomes were assessed.<br />Results: Of 9,098 women meeting inclusion criteria, 1,178 (13%) women recorded 1,521 pregnancies. The annualised incidence rate of pregnancy was 0.042 (95% CI 0.040, 0.045). A total of 635 (42%) reported pregnancies were conceived on DMT, increasing from 27% in 2006 to 62% in 2016. The median duration of DMT exposure during pregnancy was 30 days (IQR: 9, 50). There were a higher number of induced abortions on FDA pregnancy class C/D drugs compared with pregnancy class B and no DMT (p = 0.010); but no differences in spontaneous abortions, term or preterm births.<br />Conclusions: We report low pregnancy incidence rates, with increasing number of pregnancies conceived on DMT over the past 12-years. The median duration of DMT exposure in pregnancy was relatively short at one month.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Cohort Studies
Female
Follow-Up Studies
Humans
Immunologic Factors therapeutic use
Incidence
Pregnancy
Pregnancy Outcome
Registries
Retrospective Studies
Young Adult
Multiple Sclerosis, Relapsing-Remitting epidemiology
Multiple Sclerosis, Relapsing-Remitting therapy
Pregnancy Complications epidemiology
Pregnancy Complications therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2211-0356
- Volume :
- 28
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis and related disorders
- Publication Type :
- Academic Journal
- Accession number :
- 30623864
- Full Text :
- https://doi.org/10.1016/j.msard.2019.01.003