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IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Salmonella Infection.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Feb 01; Vol. 202 (3), pp. 956-965. Date of Electronic Publication: 2019 Jan 07. - Publication Year :
- 2019
-
Abstract
- The cytokine IL-22 is rapidly induced at barrier surfaces where it regulates host-protective antimicrobial immunity and tissue repair but can also enhance disease severity in some chronic inflammatory settings. Using the chronic Salmonella gastroenteritis model, Ab-mediated neutralization of IL-22 impaired intestinal epithelial barrier integrity and, consequently, exaggerated expression of proinflammatory cytokines. As disease normally resolved, neutralization of IL-22 caused luminal narrowing of the cecum-a feature reminiscent of fibrotic strictures seen in Crohn disease patients. Corresponding to the exaggerated immunopathology caused by IL-22 suppression, Salmonella burdens in the gut were reduced. This enhanced inflammation and pathogen clearance was associated with alterations in gut microbiome composition, including the overgrowth of Bacteroides acidifaciens Our findings thus indicate that IL-22 plays a protective role by limiting infection-induced gut immunopathology but can also lead to persistent pathogen colonization.<br /> (Copyright © 2019 by The American Association of Immunologists, Inc.)
- Subjects :
- Animals
Antibodies, Bacterial immunology
Antibodies, Neutralizing immunology
Bacteroides
Cecum immunology
Cecum pathology
Crohn Disease immunology
Crohn Disease pathology
Cytokines immunology
Gastroenteritis microbiology
Inflammation
Interleukins antagonists & inhibitors
Intestinal Mucosa immunology
Intestinal Mucosa pathology
Mice
Mice, Inbred C57BL
Remission Induction
Salmonella Infections, Animal therapy
Salmonella typhimurium
Interleukin-22
Gastroenteritis immunology
Gastrointestinal Microbiome
Interleukins immunology
Salmonella Infections, Animal immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 202
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 30617224
- Full Text :
- https://doi.org/10.4049/jimmunol.1801308