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Broncho-Vaxom® (OM-85 BV) soluble components stimulate sinonasal innate immunity.
- Source :
-
International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2019 Apr; Vol. 9 (4), pp. 370-377. Date of Electronic Publication: 2019 Jan 07. - Publication Year :
- 2019
-
Abstract
- Background: Broncho-Vaxom® (OM-85 BV) is an extract of infectious respiratory bacteria that is used as an immunostimulant outside of the United States for the prevention and treatment of bronchitis and rhinosinusitis. Prior studies have shown that use of OM-85 BV is associated with reduction in frequency of respiratory infection and decreased duration of antibiotic usage. However, the effects of OM-85 BV on respiratory mucosal innate immunity are unknown.<br />Methods: Human sinonasal epithelial cells were grown at an air-liquid interface (ALI). Ciliary beat frequency (CBF) and nitric oxide (NO) production in response to stimulation with OM-85 BV was measured in vitro. Pharmacologic inhibitors of bitter taste receptor (T2R) signaling were used to determine if this pathway was taste-receptor-mediated.<br />Results: Apical application of OM-85 BV resulted in an NO-mediated increase in CBF (p < 0.05) and increased NO production (p < 0.0001) when compared to saline-stimulated control cultures. ALI pretreatment with taste receptor pathway inhibitors blocked OM-85 BV-induced increases in NO.<br />Conclusion: OM-85 BV has ciliostimulatory and immunogenic properties that may be partially responsible for its observed efficacy as a respiratory therapeutic. These responses were NO-dependent and consistent with T2R activation. Further work is necessary to elucidate specific component-receptor signaling relationships.<br /> (© 2019 ARS-AAOA, LLC.)
- Subjects :
- Cells, Cultured
Cilia drug effects
Cilia physiology
Epithelial Cells drug effects
Epithelial Cells immunology
Epithelial Cells physiology
Humans
Nasal Mucosa immunology
Nasal Mucosa physiology
Nitric Oxide immunology
Adjuvants, Immunologic pharmacology
Cell Extracts pharmacology
Immunity, Innate drug effects
Nasal Mucosa drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2042-6984
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International forum of allergy & rhinology
- Publication Type :
- Academic Journal
- Accession number :
- 30615298
- Full Text :
- https://doi.org/10.1002/alr.22276