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Atopic dermatitis endotypes and implications for targeted therapeutics.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2019 Jan; Vol. 143 (1), pp. 1-11. - Publication Year :
- 2019
-
Abstract
- Recent research advancements indicate that atopic dermatitis (AD) is a complex disease characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity, filaggrin and IgE status, and underlying molecular mechanisms/endotypes. This heterogeneity advocates against the traditional "one-size-fits-all" therapeutic approaches still used to manage AD. Precision medicine approaches, striving for targeted, tailored, endotype-driven disease prevention and treatment, rely on detailed definitions of the disease's variability across different phenotypes. Studies have shown that AD harbors different endotypes across different age groups and ethnicities and according to IgE levels and filaggrin mutation status. These include European American versus Asian patients, children versus adults, intrinsic versus extrinsic (IgE status) disease, and patients with and without filaggrin mutations. Therapies targeting different cytokine axes and other mechanisms involved in disease pathogenesis, which are currently being tested for patients with AD across the disease spectrum, will expand our ability to dissect the relative contribution of each of these pathways to disease perpetuation.<br /> (Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Age Factors
Child
Child, Preschool
Female
Filaggrin Proteins
Humans
Infant
Infant, Newborn
Male
Cytokines genetics
Cytokines immunology
Dermatitis, Atopic classification
Dermatitis, Atopic ethnology
Dermatitis, Atopic genetics
Dermatitis, Atopic therapy
Immunoglobulin E genetics
Immunoglobulin E immunology
Intermediate Filament Proteins genetics
Intermediate Filament Proteins immunology
Mutation
Precision Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 143
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30612663
- Full Text :
- https://doi.org/10.1016/j.jaci.2018.10.032