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Effect of (Z)-isomer content on [ 11 C]ABP688 binding potential in humans.
- Source :
-
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2019 May; Vol. 46 (5), pp. 1175-1178. Date of Electronic Publication: 2019 Jan 03. - Publication Year :
- 2019
-
Abstract
- Purpose: To determine how the low-affinity (Z)-isomer of the radiotracer [ <superscript>11</superscript> C]ABP688 affects binding potential values in vivo in humans.<br />Methods: High-resolution [ <superscript>11</superscript> C]ABP688 PET scans were acquired on 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). The relative contents of (E)- and (Z)-isomers were determined prior to injection using analytical high-performance liquid chromatography [r <subscript>t</subscript> (E) = 10 min, r <subscript>t</subscript> (Z) = 8.5 min]. Mean binding potential [BP <subscript>ND</subscript> = f <subscript>ND</subscript> * (B <subscript>avail</subscript> /K <subscript>D</subscript> )] values were calculated in the striatum, limbic regions, and prefrontal cortex using the simplified reference tissue model with cerebellar grey matter as reference.<br />Results: Mean ± SD (E)-isomer content in [ <superscript>11</superscript> C]ABP688 production was 92 ± 3.8% (range 78-97%). Percent (E)-isomer was positively correlated with BP <subscript>ND</subscript> in the striatum (ρ = 0.28, p = 0.015) and limbic regions (ρ = 0.25, p = 0.036). In multiple regression analysis, sex (β = 0.39, p = 0.001) and (E)-isomer content (β = 0.23, p = 0.040) were significant predictors of BP <subscript>ND</subscript> .<br />Conclusions: Even modest levels of (Z)-[ <superscript>11</superscript> C]ABP688 can reduce estimates of tracer binding in vivo. Future studies should use production methods that enrich levels of (E)-[ <superscript>11</superscript> C]ABP688, report tracer isomer ratios, and account for this factor in their analyses.
Details
- Language :
- English
- ISSN :
- 1619-7089
- Volume :
- 46
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of nuclear medicine and molecular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 30607444
- Full Text :
- https://doi.org/10.1007/s00259-018-4237-3