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Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2019 Feb; Vol. 40 (2), pp. 116-127. Date of Electronic Publication: 2018 Dec 31. - Publication Year :
- 2019
-
Abstract
- RIG-I and MDA5 receptors are key sensors of pathogen-associated molecular pattern (PAMP)-containing viral RNA and transduce downstream signals to activate an antiviral and immunomodulatory response. Fifteen years of research have put them at the center of an ongoing hunt for novel pharmacological pan-antivirals, vaccine adjuvants, and antitumor strategies. Current knowledge testifies to the redundant, but also distinct, functions mediated by RIG-I and MDA5, opening opportunities for the use of specific and potent nucleic acid agonists. We critically discuss the evidence and remaining knowledge gaps that have an impact on the choice and design of optimal RNA ligands to achieve an appropriate immunostimulatory response, with limited adverse effects, for prophylactic and therapeutic interventions against viruses and cancer in humans.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adjuvants, Immunologic pharmacology
Animals
Antiviral Agents pharmacology
Autoimmune Diseases drug therapy
DEAD Box Protein 58 chemistry
DEAD Box Protein 58 immunology
Humans
Interferon-Induced Helicase, IFIH1 chemistry
Interferon-Induced Helicase, IFIH1 immunology
Ligands
Molecular Targeted Therapy
Pathogen-Associated Molecular Pattern Molecules immunology
Pathogen-Associated Molecular Pattern Molecules metabolism
DEAD Box Protein 58 metabolism
Interferon-Induced Helicase, IFIH1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3735
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30606502
- Full Text :
- https://doi.org/10.1016/j.tips.2018.12.003