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Upregulated AHIF-mediated radioresistance in glioblastoma.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 Feb 05; Vol. 509 (2), pp. 617-623. Date of Electronic Publication: 2018 Dec 31. - Publication Year :
- 2019
-
Abstract
- Long non-coding RNAs (lncRNAs) play vital roles in the pathobiology of glioblastoma multiforme (GBM). Though radiotherapy remains the most effective component of multiple therapies for patients with GBM, lncRNAs conferring GBM radioresistance are less unknown. Here, the present study identified that the antisense transcript of hypoxia-inducible factor-1α (AHIF) was upregulated in GBM cells after radiotherapy. The deregulation of AHIF affected GBM cell clonogenic formation, DNA repair and apoptosis. Notably, knockdown of AHIF inhibited tumorigenesis after radiotherapy in vivo. Further biochemical analysis identified that AHIF regulated proteins associated with apoptosis after radiotherapy. Thus, the present data illustrate that suppression of AHIF increases radiosensitivity in GBM cells, which may be a potential diagnostic and therapeutic target for GBM patients.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Apoptosis radiation effects
Cell Line, Tumor
Gene Expression Regulation, Neoplastic radiation effects
Humans
Mice
Radiation Tolerance
Brain Neoplasms genetics
Brain Neoplasms radiotherapy
Glioblastoma genetics
Glioblastoma radiotherapy
Hypoxia-Inducible Factor 1, alpha Subunit genetics
RNA, Long Noncoding genetics
Up-Regulation radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 509
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 30606477
- Full Text :
- https://doi.org/10.1016/j.bbrc.2018.12.136