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Tributyltin and perfluorooctane sulfonate play a synergistic role in promoting excess fat accumulation in Japanese medaka (Oryzias latipes) via in ovo exposure.
- Source :
-
Chemosphere [Chemosphere] 2019 Apr; Vol. 220, pp. 687-695. Date of Electronic Publication: 2018 Dec 29. - Publication Year :
- 2019
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Abstract
- The ubiquitous environmental obesogens tributyltin (TBT) and perfluorooctane sulfonate (PFOS) may accumulate in parent and be transferred to their offspring, resulting in trans-generational adverse effects. In this study, we investigated the combined toxic and obesogenic effects of TBT and PFOS on the early life stages of Japanese medaka (Oryzias latipes). In ovo nanoinjection was used to simulate the maternal transfer process. Doses were controlled at 0, 0.05, 0.5, and 2.5 ng/egg (TBT) and at 0, 0.05, 0.5, and 5.0 ng/egg (PFOS), with a full factorial design for mixture formulations. Relatively high doses of agents in mixtures were needed to induce significant mortality (TBT ≥ 0.5 ng/egg) or delayed hatching (PFOS = 5.0 ng/egg) of embryos. The interaction between TBT and PFOS in mixtures had significant effects on the observed hatching delay, but not on acute mortality. Compared with controls, separate exposure to TBT (or PFOS) notably elevated adipose areas at the doses of 0.05 and 0.5 ng/egg, but not at the highest doses. Combined exposure significantly promoted the fat accumulation in newly hatched larvae, even when the doses of TBT and PFOS were both at the levels that did not show obesogenic effect. The interactive effect of TBT and PFOS could aggravate the total obesogenic effect of their mixtures, indicating a synergistic interaction. These results highlight the importance of paying close attention to interaction effects when addressing the impacts of mixtures of environmental obesogens.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adipose Tissue growth & development
Animals
Drug Synergism
Embryo, Nonmammalian drug effects
Female
Larva drug effects
Maternal Exposure adverse effects
Obesity chemically induced
Oryzias embryology
Adipose Tissue drug effects
Alkanesulfonic Acids pharmacology
Fluorocarbons pharmacology
Oryzias metabolism
Trialkyltin Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1298
- Volume :
- 220
- Database :
- MEDLINE
- Journal :
- Chemosphere
- Publication Type :
- Academic Journal
- Accession number :
- 30605811
- Full Text :
- https://doi.org/10.1016/j.chemosphere.2018.12.191