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Biosynthesis of copper nanoparticles using aqueous Tilia extract: antimicrobial and anticancer activities.
- Source :
-
Heliyon [Heliyon] 2018 Dec 20; Vol. 4 (12), pp. e01077. Date of Electronic Publication: 2018 Dec 20 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- A cost-effective method for the biosynthesis of copper nanoparticles (Cu-NPLs) using Tilia extract under optimum conditions has been presented. The use of Tilia extracts for the synthesis of Cu-NPLs has been investigated for the first time. The Cu-NPLs are stable due to in situ bio-capping by the Tilia extract residues. Formation of metallic Cu was revealed by UV-vis and XRD analyses. UV-vis of Cu-NPLs showed an SPR characteristic peak at 563 nm (energy bandgap = 2.1 eV). Morphology and size of the as-prepared Cu-NPLs were determined using SEM and TEM studies. TEM observations show that the produced Cu-NPLs are hemispherical in shape with different diameters in the range 4.7-17.4 nm. The electrical conductivity of the Cu-NPLs was determined as 1.04 × 10 <superscript>-6</superscript> S cm <superscript>-1</superscript> (at T = 120 K). The antimicrobial studies exhibited relatively high activity against pathogenic bacteria like Gram-positive & Gram-negative bacteria. Anticancer studies demonstrated the in vitro cytotoxicity value of Cu-NPLs against tested human colon cancer Caco-2 cells, human hepatic cancer HepG2 cells and human breast cancer Mcf-7 cells. To conclude, Cu-NPLs are promising in electronic devices and they possess a potential anticancer application for some human cancer therapy as well.
Details
- Language :
- English
- ISSN :
- 2405-8440
- Volume :
- 4
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Heliyon
- Publication Type :
- Academic Journal
- Accession number :
- 30603710
- Full Text :
- https://doi.org/10.1016/j.heliyon.2018.e01077