Back to Search
Start Over
Floating molecularly imprinted polymers based on liquid crystalline and polyhedral oligomeric silsesquioxanes for capecitabine sustained release.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2019 Feb 25; Vol. 557, pp. 293-303. Date of Electronic Publication: 2018 Dec 29. - Publication Year :
- 2019
-
Abstract
- Molecularly imprinted polymers (MIPs) have drawn extensive attention as carriers on drug delivery. However, most of MIPs suffer from insufficient drug loading capacity, burst release of drugs and/or low bioavailability. To solve the issues, this study designed an imprinted material with superior floating nature for oral drug delivery system of capecitabine (CAP) rationally. The MIPs was synthesized in the presence of 4-methylphenyl dicyclohexyl ethylene (liquid crystalline, LC) and polyhedral oligomeric silsesquioxanes (POSS) via polymerization reaction. The LC-POSS MIPs had extended release of the template molecules over 13.4 h with entrapment efficiency of 20.53%, diffusion coefficient of 2.83 × 10 <superscript>-11</superscript> cm <superscript>2</superscript> s <superscript>-1</superscript> , and diffusion exponent of 0.84. Pharmacokinetic studies further revealed the prolong release and high relative bioavailability of CAP in vivo of rats, showing the effective floating effect of the LC-POSS MIPs. The in vivo images revealed visually that the gastroretentive time of the LC-POSS MIPs was longer than non-LC-POSS imprinted polymers. The physical characteristics of the polymers were also characterized by nitrogen adsorption experiment, scanning electron microscopy, thermogravimetric analysis and differential scanning calorimetry analysis. As a conclusion, the LC-POSS MIPs can be used as an eligible CAP carrier and might hold great potential in clinical applications for sustained release drug.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antimetabolites, Antineoplastic chemistry
Antimetabolites, Antineoplastic pharmacokinetics
Capecitabine chemistry
Capecitabine pharmacokinetics
Cell Survival drug effects
Delayed-Action Preparations administration & dosage
Delayed-Action Preparations chemistry
Delayed-Action Preparations pharmacokinetics
Drug Liberation
Humans
Liquid Crystals chemistry
MCF-7 Cells
Male
Models, Molecular
Organosilicon Compounds chemistry
Organosilicon Compounds pharmacokinetics
Polymers chemistry
Polymers pharmacokinetics
Rats, Wistar
Antimetabolites, Antineoplastic administration & dosage
Capecitabine administration & dosage
Molecular Imprinting
Organosilicon Compounds administration & dosage
Polymers administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 557
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 30599225
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2018.12.070