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Early and late childhood telomere length predict subclinical atherosclerosis at age 14 yrs. - The CardioCAPS study.
- Source :
-
International journal of cardiology [Int J Cardiol] 2019 Mar 01; Vol. 278, pp. 250-253. Date of Electronic Publication: 2018 Dec 22. - Publication Year :
- 2019
-
Abstract
- Introduction: Carotid Intima Media Thickness (CIMT) is a marker of subclinical atherosclerosis, associated with cardiovascular risk in adults. Telomere length (TL) is a marker of cellular ageing. We sought to determine whether telomere length in early childhood and/or at 14-years is associated with CIMT in adolescence, in a community-based cohort study.<br />Methods: 118 children had TL measured at mean age 3.6-years and 165 children had TL and CIMT, measured at 14-years, from the community-based Childhood Asthma Prevention Study.<br />Results: TL in early childhood was significantly inversely associated with CIMT at 14 years, p = 0.04. TL in teenage life was also significantly inversely associated with CIMT at 14 years, p = 0.03. This latter association was no longer significant, however, after adjusting for early life TL.<br />Conclusion: TL measured in early childhood and adolescence is significantly associated with CIMT at 14-years, suggesting that telomere length is a biological marker or even early determinant of late cardiovascular risk.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Asymptomatic Diseases epidemiology
Atherosclerosis epidemiology
Atherosclerosis physiopathology
Cohort Studies
Female
Humans
Male
Predictive Value of Tests
Prospective Studies
Telomere pathology
Atherosclerosis diagnosis
Carotid Intima-Media Thickness trends
Telomere physiology
Telomere Homeostasis physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 278
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 30595356
- Full Text :
- https://doi.org/10.1016/j.ijcard.2018.12.065