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Prophylactic use of carvedilol to prevent ventricular dysfunction in patients with cancer treated with doxorubicin.
- Source :
-
Indian heart journal [Indian Heart J] 2018 Dec; Vol. 70 Suppl 3, pp. S96-S100. Date of Electronic Publication: 2018 Jun 18. - Publication Year :
- 2018
-
Abstract
- Objective: Deterioration in ventricular function is often observed in patients treated with anthracyclines for cancer. There is a paucity of evidence on interventions that might provide cardio-protection. We investigated whether prophylactic use of carvedilol can prevent doxorubicin-induced cardiotoxicity and whether any observed effect is dose related.<br />Methods: A prospective, randomized, double-blind study in patients treated with doxorubicin, comparing placebo (n = 38) with different doses of carvedilol [6.25 mg/day (n = 41), 12.5 mg/day (n = 38) or 25 mg/day (n = 37)]. The primary endpoint was the measured change in left ventricular ejection fraction (LVEF) from baseline to 6 months.<br />Results: LVEF decreased from 62 ± 5% at baseline to 58 ± 7% at 6-months (p = 0.002) in patients assigned to placebo but no statistically significant changes were observed in any of the 3 carvedilol groups. At 6 months, only one of 116 patients (1%) assigned to carvedilol had an LVEF < 50% compared to four of the 38 assigned to placebo (11%), (p = 0.013). No significant differences were noted between carvedilol and placebo in terms of the development of diastolic dysfunction, clinically overt heart failure or death.<br />Conclusions: Carvedilol might prevent deterioration in LVEF in cancer patients treated with doxorubicin. This effect may not be dose related within the studied range.<br /> (Copyright © 2018. Published by Elsevier B.V.)
- Subjects :
- Adult
Antibiotics, Antineoplastic adverse effects
Antibiotics, Antineoplastic therapeutic use
Antioxidants therapeutic use
Double-Blind Method
Doxorubicin therapeutic use
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Ventricular Dysfunction, Left chemically induced
Ventricular Dysfunction, Left physiopathology
Carvedilol therapeutic use
Doxorubicin adverse effects
Neoplasms drug therapy
Stroke Volume drug effects
Ventricular Dysfunction, Left prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 2213-3763
- Volume :
- 70 Suppl 3
- Database :
- MEDLINE
- Journal :
- Indian heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 30595329
- Full Text :
- https://doi.org/10.1016/j.ihj.2018.06.011