Acute Decompensated Heart Failure After Initiation of Amiodarone in a Patient With Anderson-Fabry Disease.

Authors :: Fine NM
Wang Y
Khan A
Source :: The Canadian journal of cardiology [Can J Cardiol] 2019 Jan; Vol. 35 (1), pp. 104.e5-104.e7. Date of Electronic Publication: 2018 Oct 16.
Publication Year :: 2019
Abstract: A 54-year-old man with the lysosomal storage disorder Anderson-Fabry disease (AFD) and cardiac involvement was placed on amiodarone for treatment of symptomatic paroxysmal atrial fibrillation. Shortly thereafter, he developed symptoms of acute decompensated heart failure, requiring hospital admission. Endomyocardial biopsy demonstrated findings consistent with AFD and possible amiodarone toxicity. Amiodarone was discontinued, and the patient's heart failure resolved with return to baseline status. Amiodarone is known to alter lysosomal pH and enzyme activity, and this case illustrates how it should be used with considerable caution in patients with AFD.<br /> (Copyright © 2018 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.)

Subjects :: Acute Disease
Administration, Oral
Amiodarone administration & dosage
Biopsy
Cytochrome P-450 CYP1A2 Inhibitors administration & dosage
Cytochrome P-450 CYP1A2 Inhibitors adverse effects
Echocardiography
Fabry Disease diagnosis
Heart Failure diagnosis
Heart Failure physiopathology
Humans
Male
Middle Aged
Myocardium pathology
Stroke Volume physiology
Amiodarone adverse effects
Fabry Disease drug therapy
Heart Failure chemically induced

Full Text Access

Tools