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Commentary: EPA's proposed expansion of dose-response analysis is a positive step towards improving its ecological risk assessment.
- Source :
-
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2019 Mar; Vol. 246, pp. 566-570. Date of Electronic Publication: 2018 Dec 18. - Publication Year :
- 2019
-
Abstract
- The United States Environmental Protection Agency (US EPA) has recently proposed changes to strengthen the transparency of its pivotal regulatory science policy and procedures. In this context, the US EPA aims to enhance the transparency of dose-response data and models, proposing to consider for the first time non-linear biphasic dose-response models. While the proposed changes have the potential to lead to markedly improved ecological risk assessment compared to past and current approaches, we believe there remain open issues for improving the quality of ecological risk assessment, such as the consideration of adaptive, dynamic and interactive effects. Improved risk assessment including adaptive and dynamic non-linear models (beyond classic threshold models) can enhance the quality of regulatory decisions and the protection of ecological health. We suggest that other countries consider adopting a similar scientific-regulatory posture with respect to dose-response modeling via the inclusion of non-linear biphasic models, that incorporate the dynamic potential of biological systems to adapt (i.e., enhancing positive biological endpoints) or maladapt to low levels of stressor agents.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Dose-Response Relationship, Drug
Ecology legislation & jurisprudence
Ecology statistics & numerical data
Humans
Nonlinear Dynamics
Risk Assessment legislation & jurisprudence
Risk Assessment statistics & numerical data
United States
United States Environmental Protection Agency
Ecology methods
Government Regulation
Risk Assessment methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6424
- Volume :
- 246
- Database :
- MEDLINE
- Journal :
- Environmental pollution (Barking, Essex : 1987)
- Publication Type :
- Academic Journal
- Accession number :
- 30594897
- Full Text :
- https://doi.org/10.1016/j.envpol.2018.12.046