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The Asymmetric Aza-silyl-Prins Reaction: Synthesis of Enantiopure Piperidines.
- Source :
-
Organic letters [Org Lett] 2019 Jan 18; Vol. 21 (2), pp. 350-355. Date of Electronic Publication: 2018 Dec 28. - Publication Year :
- 2019
-
Abstract
- The design and development of the first asymmetric aza-silyl-Prins reaction is reported, giving rise to valuable and diverse piperidines and pipecolic acid derivatives in both high yields and as single enantiomers. The creation of a novel chiral auxiliary-homoallylic amine for the aza-silyl-Prins reaction is essential to its success.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 21
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 30592613
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b03283