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Gender-related issues in the pharmacology of new anti-obesity drugs.
- Source :
-
Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2019 Mar; Vol. 20 (3), pp. 375-384. Date of Electronic Publication: 2018 Dec 27. - Publication Year :
- 2019
-
Abstract
- Four new medicines-liraglutide, lorcaserin, bupropion/naltrexone, and phentermine/topiramate-have been recently added to the pharmacological arsenal for obesity treatment and could represent important tools to manage this epidemic disease. To achieve satisfactory anti-obesity goals, the use of these new medicines should be optimized and tailored to specific patient subpopulations also by applying dose adjustments if needed. In the present review, we posit that gender could be among the factors influencing the activity of the new obesity drugs both because of pharmacokinetic and pharmacodynamic factors. Although evidence from premarketing clinical studies suggested that no dose adjustment by gender is necessary for any of these new medicines, these studies were not specifically designed to identify gender-related differences. This observation, together with the strong theoretical background supporting the hypothesis of a gender-dimorphic response, strongly call upon an urgent need of new real-life data on gender-related difference in the pharmacology of these new obesity drugs.<br /> (© 2018 World Obesity Federation.)
- Subjects :
- Anti-Obesity Agents therapeutic use
Benzazepines pharmacology
Benzazepines therapeutic use
Bupropion pharmacology
Bupropion therapeutic use
Dose-Response Relationship, Drug
Drug Combinations
Female
Humans
Liraglutide pharmacology
Liraglutide therapeutic use
Male
Naltrexone pharmacology
Naltrexone therapeutic use
Patient Selection
Sex Factors
Topiramate pharmacology
Topiramate therapeutic use
Treatment Outcome
Anti-Obesity Agents pharmacology
Obesity drug therapy
Weight Loss drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1467-789X
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Obesity reviews : an official journal of the International Association for the Study of Obesity
- Publication Type :
- Academic Journal
- Accession number :
- 30589980
- Full Text :
- https://doi.org/10.1111/obr.12805