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[The histopathology and immunohistochemistry of granular cell tumour. A study of 12 cases with a brief historical note].
- Source :
-
Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia [Rev Esp Patol] 2019 Jan - Mar; Vol. 52 (1), pp. 11-19. Date of Electronic Publication: 2018 Jul 06. - Publication Year :
- 2019
-
Abstract
- Introduction and Objective: Granular cell tumour (GCT) is a benign neoplasm of neural/schwannian origin, usually presenting as a single asymptomatic lesion, mainly located in the dermis and subcutaneous tissue or submucosa, although multiple tumours may occur. Microscopically, GCTs are composed of large cells with abundant eosinophilic, granular cytoplasm arranged in sheets, nests, cords or trabeculae. Based on the cytological characteristics and the presence of necrosis, three types are recognized: benign, atypical and malignant. We aim to present the cytological and immunohistochemical characteristics of 12 granular cell tumours.<br />Materials and Methods: 12 cases of GCT were selected from the consultation files of one of the authors (COH) The paraffin embedded tissue was processed for immunostaining with S-100 protein, calretinin, CD68, α-inhibin, PGP9.5, CD57 (Leu7), CD63 (NKI / C3), Gap43 (growth-associated protein-43), SOX10, TFE-3 and Ki-67.<br />Results and Conclusions: 6 male and 6 female patients, with an average age of 40, made up the study group. The most frequent location for the tumours was in the subcutaneous soft tissues of the arms. There were no malignant cases. All tumours were positive for S-100, CD57, SOX10, calretinin, CD68, PGP9.5, α-inhibin and TFE-3, with a low Ki-67 (1-5%). Additionally, we reported, for the first time, the positive immunoreaction to Gap43 (growth-associated protein-43) in GCT.<br /> (Copyright © 2018 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Adult
Aged
Antigens, CD analysis
Antigens, Differentiation, Myelomonocytic analysis
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors analysis
CD57 Antigens analysis
Calbindin 2 analysis
Child
Female
GAP-43 Protein analysis
Humans
Inhibins analysis
Ki-67 Antigen analysis
Male
Middle Aged
S100 Proteins analysis
SOXE Transcription Factors analysis
Tetraspanin 30 analysis
Ubiquitin Thiolesterase analysis
Young Adult
Granular Cell Tumor chemistry
Granular Cell Tumor pathology
Soft Tissue Neoplasms chemistry
Soft Tissue Neoplasms pathology
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1988-561X
- Volume :
- 52
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia
- Publication Type :
- Academic Journal
- Accession number :
- 30583826
- Full Text :
- https://doi.org/10.1016/j.patol.2018.05.004