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cd44 deletion suppresses atypia in the precancerous mouse testis.
- Source :
-
Molecular carcinogenesis [Mol Carcinog] 2019 May; Vol. 58 (5), pp. 621-626. Date of Electronic Publication: 2019 Jan 28. - Publication Year :
- 2019
-
Abstract
- Loss-of-function of RHAMM causes hypofertility and testicular atrophy in young mice, followed by germ cell neoplasia in situ (GCNIS) of the testis, cellular atypia, and development of the testicular germ cell tumor (TGCT) seminoma. These pathologies reflect the risk factors and phenotypes that precede seminoma development in humans and-given the high prevalence of RHAMM downregulation in human seminoma-link RHAMM dysfunction with the aetiology of male hypofertility and GCNIS-related TGCTs. The initiating event underlying these pathologies, in RHAMM mutant testis, is premature displacement of undifferentiated progenitors from the basal compartment. We hypothesized that cd44 (both cancer initiating cell- and oncogenic progression marker) will drive GCNIS development, induced by RHAMM-loss-of-function in the mouse. We report that cd44 is expressed in a specific subset of GCNIS testes. Its genetic deletion has no effect on GCNIS onset, but it ameliorates oncogenic progression. We conclude that cd44 expression, combined with RHAMM dysfunction, promotes oncogenic progression in the testis.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Biomarkers, Tumor genetics
Carcinoma in Situ genetics
Carcinoma in Situ metabolism
Female
Infertility, Male genetics
Infertility, Male metabolism
Male
Mice
Mice, Transgenic
Neoplasms, Germ Cell and Embryonal genetics
Neoplasms, Germ Cell and Embryonal metabolism
Precancerous Conditions genetics
Precancerous Conditions metabolism
Sequence Deletion
Testicular Neoplasms genetics
Testicular Neoplasms metabolism
Carcinoma in Situ prevention & control
Extracellular Matrix Proteins physiology
Hyaluronan Receptors physiology
Infertility, Male prevention & control
Neoplasms, Germ Cell and Embryonal prevention & control
Precancerous Conditions prevention & control
Testicular Neoplasms prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1098-2744
- Volume :
- 58
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecular carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 30582228
- Full Text :
- https://doi.org/10.1002/mc.22961