Back to Search
Start Over
Impact of hepatitis C virus and direct acting antivirals on kidney recipients: a retrospective study.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2019 May; Vol. 32 (5), pp. 493-501. Date of Electronic Publication: 2019 Jan 11. - Publication Year :
- 2019
-
Abstract
- Hepatitis C virus (HCV) in kidney transplanted patients (KTx-p) carries a high risk for a worse outcome. This retrospective study evaluates the impact of HCV and of the new direct acting antivirals (DAAs) on patient and graft outcomes in KTx patients. Forty (6.5%) of the 616 KTx-p, who received a kidney transplantation (KTx) in our Centre had antibodies against HCV: 13 were positive for HCV RNA and received DAAs (Group A); 11 were HCV RNA positive and did not receive any treatment (Group B; n = 11); 16 were negative for HCV RNA (Group C). All Group A patients had HCV RNA negativity after 12 weeks of treatment, and 12 (92.30%) achieved a sustained virological response (SVR). Only two patients, who had proteinuria greater than 500 mg/day showed a worsening of proteinuria after antiviral therapy in Group A. Liver enzyme elevation and death were significantly more frequent in Group B than other groups. Our results support the notion that active HCV infection negatively affects kidney recipients and that DAA have a high safety and efficacy profile after KTx with no significant negative effect on allograft function, particularly in well-functioning renal grafts.<br /> (© 2018 Steunstichting ESOT.)
- Subjects :
- Adult
Disease Progression
Drug Therapy, Combination
Female
Hepacivirus
Humans
Kidney physiology
Kidney Failure, Chronic complications
Kidney Failure, Chronic virology
Liver enzymology
Male
Middle Aged
Patient Safety
Proteinuria
Retrospective Studies
Sustained Virologic Response
Antiviral Agents therapeutic use
Hepatitis C, Chronic drug therapy
Kidney Failure, Chronic surgery
Kidney Transplantation
Simeprevir therapeutic use
Sofosbuvir therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2277
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 30580473
- Full Text :
- https://doi.org/10.1111/tri.13393