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Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation.
- Source :
-
Biomolecules [Biomolecules] 2018 Dec 20; Vol. 9 (1). Date of Electronic Publication: 2018 Dec 20. - Publication Year :
- 2018
-
Abstract
- Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 30577528
- Full Text :
- https://doi.org/10.3390/biom9010001