Cytotoxic limonoids from the bark of Walsura cochinchinensis.

Authors :: Trinh BTD
Nguyen HD
Nguyen HT
Pham PD
Ngo NTN
Nguyen LT
Nguyen LTT
Bui DN
Dang SV
Nguyen LD
Source :: Fitoterapia [Fitoterapia] 2019 Mar; Vol. 133, pp. 75-79. Date of Electronic Publication: 2018 Dec 19.
Publication Year :: 2019
Abstract: Three new limonoids, walsucochinones A-C (1-3), along with eight known compounds, were isolated from an ethyl acetate extract of the bark of Walsura cochinchinensis. Their structures were determined using spectroscopic techniques, mainly 1-D and 2-D NMR. The ethyl acetate extract showed cytotoxic activity against MCF-7 human breast cancer cells and cytotoxicity of the isolated compounds were evaluated in vitro using the SRB assay. Walsucochinone C (3) exhibited the most active effect with IC <subscript>50</subscript> value of 16.4 ± 0.2 μM.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)