Investigating the Correlation of Ktrans With Semi-Quantitative MRI Parameters Towards More Robust and Reproducible Perfusion Imaging Biomarkers in Three Cancer Types.

MRI Imaging biomarkers (IBs) have the potential to deliver quantitative cancer descriptors of pathophysiology for non-invasively screening, diagnosing, and monitoring cancer patients across the cancer continuum. Despite a worldwide effort to standardize IBs involving major cancer organizations, significant variability of MR-based imaging biomarker across sites still hampers their clinical translation calling for more research in the field. To this end, in the present study quantitative and semi-quantitative approaches for perfusion biomarkers are compared in MRI data from three different cancer types. In particular, Ktrans a widely used but often variable across sites candidate biomarker is compared to a semi-quantitative perfusion MRI imaging biomarker (Wash-in WIN) in patients with breast, head, and neck and soft tissue sarcoma. Our results demonstrated a linear relationship between WIN and Ktrans in all cancer patients groups when a goodness of fit (high R ² ) criterion for ensuring adequate data quality and accuracy is met. This consistent correlation across three different cancer types indicates that the proposed semi-quantitative perfusion MRI IB can be a simpler, more robust and reproducible alternative to Ktrans for quantitative perfusion studies in oncology.