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Serum neurotrophins at birth correlate with respiratory and neurodevelopmental outcomes of premature infants.
- Source :
-
Pediatric pulmonology [Pediatr Pulmonol] 2019 Mar; Vol. 54 (3), pp. 303-312. Date of Electronic Publication: 2018 Dec 21. - Publication Year :
- 2019
-
Abstract
- Objective: Preterm birth is a significant cause of infant morbidity and mortality, which are primarily the result of respiratory and neurodevelopmental complications. However, no objective biomarker is currently available to predict at birth the risk and severity of such complications. Thus, we sought to determine whether serum neurotrophins concentrations measured at birth correlate with risk for later development of bronchopulmonary dysplasia (BPD) and long-term neurodevelopmental outcomes.<br />Methods: This study prospectively included 223 newborns admitted to neonatal intensive care units (NICU) and divided into three groups: (i) preterm infants who developed BPD; (ii) preterm infants who did not develop BPD; (iii) term infants. An exploratory cohort was enrolled in West Virginia, followed by a validation cohort recruited in four NICUs in Ohio. Specimens for serum and tracheal neurotrophins concentrations were collected within 48 h of admission. Infants requiring a fraction of inspired oxygen >0.21 for at least 28 days were diagnosed with BPD. Neurodevelopmental outcomes were extrapolated from Bayley Scales of Infant Development-Third Edition (BSID-III) administered at the 24-month follow-up visit.<br />Results: Serum brain-derived neurotrophic factor (BDNF) concentration at birth had significant negative correlation with later diagnosis of BPD (P = 0.011) and with duration of invasive ventilation and oxygen supplementation (P = 0.009 and 0.015, respectively). Serum nerve growth factor (NGF) concentration at birth had significant positive correlation with BSID-III cognitive and language composite scores at 24 months (P < 0.001 and 0.010, respectively).<br />Conclusions: These data suggest that serum neurotrophins concentrations measured at birth provide prognostic information on subsequent respiratory and neurodevelopmental outcomes.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Brain-Derived Neurotrophic Factor metabolism
Cohort Studies
Female
Humans
Infant
Infant, Newborn
Infant, Premature metabolism
Intensive Care Units, Neonatal
Male
Nerve Growth Factor metabolism
Ohio
Prognosis
Trachea metabolism
West Virginia epidemiology
Brain-Derived Neurotrophic Factor blood
Bronchopulmonary Dysplasia epidemiology
Infant, Premature blood
Infant, Premature, Diseases epidemiology
Nerve Growth Factor blood
Neurodevelopmental Disorders epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1099-0496
- Volume :
- 54
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pediatric pulmonology
- Publication Type :
- Academic Journal
- Accession number :
- 30575339
- Full Text :
- https://doi.org/10.1002/ppul.24218