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Genetic susceptibilty and celiac disease: what role do HLA haplotypes play?
- Source :
-
Acta bio-medica : Atenei Parmensis [Acta Biomed] 2018 Dec 17; Vol. 89 (9-S), pp. 17-21. Date of Electronic Publication: 2018 Dec 17. - Publication Year :
- 2018
-
Abstract
- Celiac disease is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed individuals. Many genes involved in the pathogenesis have been identified and a crucial role is known to be played by the Human Leukocyte Antigen (HLA) system. The main determinants for genetic susceptibility are HLA-DQA1 and HLA-DQB1 genes encoding for HLA-DQ2 and HLA-DQ8 molecules, carried by almost all patients affected. However, since HLA-DQ2 and HLA-DQ8 heterodimers explain almost 40% of the disease heritability, HLA typing should not be applied in diagnosis, but exclusively to clarify uncertain diagnoses, considering its negative predictive value.
Details
- Language :
- English
- ISSN :
- 2531-6745
- Volume :
- 89
- Issue :
- 9-S
- Database :
- MEDLINE
- Journal :
- Acta bio-medica : Atenei Parmensis
- Publication Type :
- Academic Journal
- Accession number :
- 30561391
- Full Text :
- https://doi.org/10.23750/abm.v89i9-S.7953