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Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

Authors :
Clemens JQ
Mullins C
Ackerman AL
Bavendam T
van Bokhoven A
Ellingson BM
Harte SE
Kutch JJ
Lai HH
Martucci KT
Moldwin R
Naliboff BD
Pontari MA
Sutcliffe S
Landis JR
Source :
Nature reviews. Urology [Nat Rev Urol] 2019 Mar; Vol. 16 (3), pp. 187-200.
Publication Year :
2019

Abstract

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. The first phase, MAPP I, included >1,000 participants who completed an intensive baseline assessment followed by a 12-month observational follow-up period. MAPP I studies showed that UCPPS pain and urinary symptoms co-vary, with only moderate correlation, and should be evaluated separately and that symptom flares are common and can differ considerably in intensity, duration and influence on quality of life. Longitudinal clinical changes in UCPPS correlated with structural and functional brain changes, and many patients experienced global multisensory hypersensitivity. Additionally, UCPPS symptom profiles were distinguishable by biological correlates, such as immune factors. These findings indicate that patients with UCPPS have objective phenotypic abnormalities and distinct biological characteristics, providing a new foundation for the study and clinical management of UCPPS.

Details

Language :
English
ISSN :
1759-4820
Volume :
16
Issue :
3
Database :
MEDLINE
Journal :
Nature reviews. Urology
Publication Type :
Academic Journal
Accession number :
30560936
Full Text :
https://doi.org/10.1038/s41585-018-0135-5