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Accelerating water exchange in Gd III -DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Jan 03; Vol. 55 (4), pp. 513-516. - Publication Year :
- 2019
-
Abstract
- The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 55
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 30556079
- Full Text :
- https://doi.org/10.1039/c8cc08556k