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Effects of Early Initiation of Solid Versus Liquid Diet after Endoscopic Submucosal Dissection on Quality of Life and Postoperative Outcomes: A Prospective Pilot Randomized Controlled Trial.
- Source :
-
Digestion [Digestion] 2019; Vol. 100 (3), pp. 160-169. Date of Electronic Publication: 2018 Dec 14. - Publication Year :
- 2019
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Abstract
- Background/aims: Feeding recommendations after endoscopic submucosal dissection (ESD) for gastric neoplasms are not established and based on clinical experience.<br />Methods: This was a prospective pilot randomized controlled trial. Patients undergoing ESD for gastric neoplasms were randomly assigned to solid (n = 50) or liquid diet (n = 50) groups. Beginning the day after hemostasis confirmation until discharge, the solid diet group started on a diet of rice porridge, whereas the liquid diet group started on a liquid diet, with gradual transition to solid food. The primary endpoint was delayed bleeding rate. The secondary endpoints were quality of life (QOL), ulcer-stage, hospital fees, and post-ESD symptoms.<br />Results: Delayed bleeding occurred in the solid diet group (2%) but not in the liquid diet group. The QOL evaluation using European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-STO22 showed better score in the solid diet group. The patients who felt dietary restriction at discharge was of a larger number in the liquid diet group (p = 0.019). More patients experienced appetite loss (p = 0.038), constipation (p = 0.022), and dietary restriction (p = 0.037) in the liquid diet group during hospitalization. The other endpoints were equivalent between the groups.<br />Conclusion: Early initiation of solid foods after ESD is feasible and associated with higher QOL, potentially rendering conventional liquid diets unnecessary, although additional studies are needed (Trial registration number: UMIN000013297).<br /> (© 2018 The Author(s) Published by S. Karger AG, Basel.)
- Subjects :
- Aged
Aged, 80 and over
Endoscopic Mucosal Resection methods
Endoscopic Mucosal Resection rehabilitation
Feasibility Studies
Female
Gastroscopy methods
Gastroscopy rehabilitation
Humans
Male
Middle Aged
Nutrition Therapy adverse effects
Pilot Projects
Postoperative Care adverse effects
Postoperative Care methods
Postoperative Complications etiology
Prospective Studies
Stomach Neoplasms surgery
Time Factors
Treatment Outcome
Endoscopic Mucosal Resection adverse effects
Gastroscopy adverse effects
Nutrition Therapy methods
Postoperative Complications prevention & control
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9867
- Volume :
- 100
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Digestion
- Publication Type :
- Academic Journal
- Accession number :
- 30554216
- Full Text :
- https://doi.org/10.1159/000494490