Long non-coding RNA DLEU1 exerts an oncogenic function in non-small cell lung cancer.

Authors :: Zhang S
Guan Y
Liu X
Ju M
Zhang Q
Source :: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2019 Jan; Vol. 109, pp. 985-990. Date of Electronic Publication: 2018 Nov 05.
Publication Year :: 2019
Abstract: Objective: To explore the role of long non-coding RNA DLEU1 in the tumorigenesis and progression of non-small cell lung cancer (NSCLC) and the underlying mechanisms.<br />Methods: The expression of DLEU1 in NSCLC tumor tissues and adjacent normal tissues was evaluated using bioinformatics analysis and qPCR. The effects of DLEU1 overexpression or deficiency on cell proliferation, apoptosis, migration and invasion were explored experimentally. Additionally, the impact of DLEU1 up-regulation on tumourigenesis was also assessed in vivo.<br />Results: The expression of DLEU1 was up-regulated in NSCLC tumor tissues. DLEU1 overexpression promoted the proliferation, migration, and invasion, but inhibited the apoptosis of NSCLC cells by upregulating CDK1 expression, binding with SRC and altering the expression of P70(S6K), MMP2 and E-cadherin. Besides, xenograft tumors in nude mice demonstrated that DLEU1 overexpression accelerated tumor growth.<br />Conclusions: DLEU1 promoted tumorigenesis and progression of NSCLC, and might be a promising therapeutic target for NSCLC.<br /> (Copyright © 2018 Elsevier Masson SAS. All rights reserved.)

Subjects :: A549 Cells
Animals
Carcinogenesis pathology
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung pathology
Female
Humans
Lung Neoplasms genetics
Lung Neoplasms pathology
Mice
Mice, Inbred BALB C
Mice, Nude
RNA, Long Noncoding
Tumor Suppressor Proteins genetics
Xenograft Model Antitumor Assays methods
Carcinogenesis metabolism
Carcinoma, Non-Small-Cell Lung metabolism
Lung Neoplasms metabolism
Tumor Suppressor Proteins biosynthesis

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