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High risk of spontaneous preterm birth among infants with gastroschisis.
- Source :
-
American journal of medical genetics. Part A [Am J Med Genet A] 2019 Jan; Vol. 179 (1), pp. 37-42. Date of Electronic Publication: 2018 Dec 14. - Publication Year :
- 2019
-
Abstract
- We examined the association between gastroschisis and preterm birth (PTB, <37 weeks) by subtype. The sample was drawn from singleton live births in California from 2007 to 2012 contained in a birth cohort file maintained by the California Office of Statewide Health Planning and Development (n = 2,891,965; 1,421 with gastroschisis). Relative risks (RRs) and 95% confidence intervals (CIs) were calculated for PTB by gestational age (<34, 34-36, and any <37 weeks) and by type (spontaneous labor with intact membranes, preterm premature rupture of the membranes [PPROM], provider initiated) and were adjusted for maternal characteristics. Over 44.5% of infants with gastroschisis were born preterm because of spontaneous etiologies; notably, 8.4% of infants with gastroschisis were born <34 weeks because of spontaneous etiologies (adjusted RRs 9.1-12.2). Overall, 53.7% of infants with gastroschisis were born preterm compared with only 6.9% of infants without gastroschisis (adjusted RR 15.2, 95% CI 13.6-19.5) and are at particularly high risk of spontaneous PTB. Nearly 9% of infants with gastroschisis delivered <34 weeks, regardless of preterm etiology, indicating that these infants are at great risk for PTB morbidities in addition to the complications from gastroschisis.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
California epidemiology
Cohort Studies
Female
Fetal Membranes, Premature Rupture physiopathology
Gastroschisis complications
Gastroschisis physiopathology
Gestational Age
Humans
Infant
Infant, Newborn
Pregnancy
Pregnancy Complications physiopathology
Pregnancy Outcome epidemiology
Premature Birth physiopathology
Retrospective Studies
Risk Factors
Young Adult
Fetal Membranes, Premature Rupture epidemiology
Gastroschisis embryology
Pregnancy Complications epidemiology
Premature Birth epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4833
- Volume :
- 179
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics. Part A
- Publication Type :
- Academic Journal
- Accession number :
- 30549407
- Full Text :
- https://doi.org/10.1002/ajmg.a.60675