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Characterization of Patients with Ibuprofen Hypersensitivity.
- Source :
-
International archives of allergy and immunology [Int Arch Allergy Immunol] 2019; Vol. 178 (2), pp. 177-181. Date of Electronic Publication: 2018 Dec 13. - Publication Year :
- 2019
-
Abstract
- Background: Ibuprofen is the most frequently used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) in North America. While it has been commonly implicated in drug-induced hypersensitivity reactions, there is limited literature specifically on ibuprofen hypersensitivity.<br />Objectives: To characterize the demographics and clinical course of hypersensitivity reactions in a cohort of patients with ibuprofen allergy.<br />Methods: A retrospective chart review of patients diagnosed with ibuprofen allergy was conducted between 2008 and 2016 in an allergy clinic at a tertiary care academic institution. Demographics and clinical information were obtained, and severity of reactions was assessed by a standardized grading system.<br />Results: A total of 41 patients were included of whom 27 were female. The mean age at first reaction to ibuprofen was 33 ± 13.9 years. The medi an time from the first reaction to the time of diagnosis was 1 year (0-3). The median time from ibuprofen exposure to the onset of symptoms was 30 min (16-101). The median duration of symptoms was 180 min (60-1,440). Urticaria and angioedema were seen in 90% of patients. The reactions were either mild (46%) or moderate (51%) in severity, but 1 patient had severe anaphylaxis. Cross-reactivity to other NSAIDs or acetaminophen was seen and presented with mostly mild reactions.<br />Conclusion: In our cohort of patients, ibuprofen hypersensitivity affected females more commonly than males, and presented with mainly cutaneous manifestations. Onset of symptoms was rapid (< 60 min). Reactions typically ranged in severity from mild to moderate although there was a risk of severe anaphylaxis. There was potential cross-reactivity with other NSAIDs or acetaminophen. The results of our study contribute to the understanding of the demographics and clinical course of ibuprofen hypersensitivity reactions.<br /> (© 2018 S. Karger AG, Basel.)
- Subjects :
- Adult
Cross Reactions
Female
Humans
Male
Middle Aged
Organ Specificity immunology
Retrospective Studies
Severity of Illness Index
Skin Tests
Symptom Assessment
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Drug Hypersensitivity diagnosis
Drug Hypersensitivity immunology
Ibuprofen adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0097
- Volume :
- 178
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International archives of allergy and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30544107
- Full Text :
- https://doi.org/10.1159/000494388