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Successful Treatment of Relapsed Pediatric Acute Myeloid Leukemia Presenting as Central Nervous System Myeloid Sarcoma: A Single-Institution Case Series.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2020 May; Vol. 42 (4), pp. 319-321. - Publication Year :
- 2020
-
Abstract
- Relapsed acute myeloid leukemia presenting as an isolated central nervous system myeloid sarcoma (CNS MS) is very rare and generally entails poor outcomes. CNS MS treatment is not well defined and can include systemic chemotherapy, intrathecal chemotherapy, radiation therapy, or hematopoietic stem cell transplant. Thiotepa, vinorelbine, topotecan, and clofarabine (TVTC) has been successful for reinduction therapy in relapsed/refractory leukemia to induce remission before hematopoietic stem cell transplant. There is no published evidence of TVTC being utilized for CNS MS. In this series, we report 2 symptomatic patients with isolated CNS MS at relapse who demonstrated near complete resolution after reinduction with TVTC and additional intrathecal chemotherapy.
- Subjects :
- Child, Preschool
Clofarabine administration & dosage
Female
Humans
Injections, Spinal
Thiotepa administration & dosage
Topotecan administration & dosage
Vinorelbine administration & dosage
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Central Nervous System Neoplasms diagnosis
Central Nervous System Neoplasms drug therapy
Leukemia, Myeloid, Acute diagnosis
Leukemia, Myeloid, Acute drug therapy
Sarcoma, Myeloid diagnosis
Sarcoma, Myeloid drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 42
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 30543582
- Full Text :
- https://doi.org/10.1097/MPH.0000000000001383