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The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial.
- Source :
-
Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2019 Apr 01; Vol. 168 (2), pp. 315-338. - Publication Year :
- 2019
-
Abstract
- The GMO90+ project was designed to identify biomarkers of exposure or health effects in Wistar Han RCC rats exposed in their diet to 2 genetically modified plants (GMP) and assess additional information with the use of metabolomic and transcriptomic techniques. Rats were fed for 6-months with 8 maize-based diets at 33% that comprised either MON810 (11% and 33%) or NK603 grains (11% and 33% with or without glyphosate treatment) or their corresponding near-isogenic controls. Extensive chemical and targeted analyses undertaken to assess each diet demonstrated that they could be used for the feeding trial. Rats were necropsied after 3 and 6 months. Based on the Organization for Economic Cooperation and Development test guideline 408, the parameters tested showed a limited number of significant differences in pairwise comparisons, very few concerning GMP versus non-GMP. In such cases, no biological relevance could be established owing to the absence of difference in biologically linked variables, dose-response effects, or clinical disorders. No alteration of the reproduction function and kidney physiology was found. Metabolomics analyses on fluids (blood, urine) were performed after 3, 4.5, and 6 months. Transcriptomics analyses on organs (liver, kidney) were performed after 3 and 6 months. Again, among the significant differences in pairwise comparisons, no GMP effect was observed in contrast to that of maize variety and culture site. Indeed, based on transcriptomic and metabolomic data, we could differentiate MON- to NK-based diets. In conclusion, using this experimental design, no biomarkers of adverse health effect could be attributed to the consumption of GMP diets in comparison with the consumption of their near-isogenic non-GMP controls.<br /> (© The Author 2018. Published by Oxford University Press on behalf of the Society of Toxicology.)
- Subjects :
- Animal Feed standards
Animals
Consumer Product Safety
Edible Grain genetics
Female
Food, Genetically Modified standards
Male
Plants, Genetically Modified genetics
Rats
Rats, Wistar
Toxicity Tests methods
Zea mays chemistry
Animal Feed toxicity
Edible Grain chemistry
Food, Genetically Modified toxicity
Plants, Genetically Modified chemistry
Zea mays genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0929
- Volume :
- 168
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Toxicological sciences : an official journal of the Society of Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 30535037
- Full Text :
- https://doi.org/10.1093/toxsci/kfy298