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Haptoglobin levels are influenced by Hp1-Hp2 polymorphism, obesity, inflammation, and hypertension in type 2 diabetes mellitus.

Authors :
Rodrigues KF
Pietrani NT
Carvalho LML
Bosco AA
Sandrim VC
Ferreira CN
Gomes KB
Source :
Endocrinologia, diabetes y nutricion [Endocrinol Diabetes Nutr (Engl Ed)] 2019 Feb; Vol. 66 (2), pp. 99-107. Date of Electronic Publication: 2018 Oct 24.
Publication Year :
2019

Abstract

Background: Type 2 diabetes mellitus (T2DM) is an inflammatory condition associated to obesity and increased oxidative stress. Haptoglobin (Hp) is an acute phase reactant that scavenges extracorpuscular hemoglobin from circulation and prevents heme-iron oxidative damage.<br />Objective: To assess the association between Hp levels and Hp1-Hp2 gene polymorphism and clinical and laboratory parameters in patients with T2DM.<br />Methods: The study sample consisted of 102 T2DM patients and 62 controls. Hp plasma levels were measured using an ELISA assay, and Hp genotyping was performed using a specific two-step allelic polymerase chain reaction.<br />Results: Hp levels were higher in T2DM patients as compared to controls (p=0.005). T2DM patients with high blood pressure had higher Hp levels than patients without this comorbidity (p=0.021). Obese T2DM patients had higher Hp levels as compared to obese controls (p=0.009) and to non-obese T2DM patients (p=0.003). The Hp1-Hp1 genotype was showed to be associated to T2DM according to additive (OR=3.038, 95% CI 1.127-8.192; p=0.036) and dominant model (OR=0.320, 95% CI 0.118-0.839; p=0.010), but Hp2 allele carriers contributed with higher Hp levels in T2DM as compared to controls. Waist circumference (p=0.002), BMI (p=0.001), and IL-6 (p=0.012), and hs-CRP (p=0.001) levels positively correlated with Hp levels in the T2DM group.<br />Conclusion: These results suggest that Hp levels are influenced by Hp1-Hp2 polymorphism, obesity, inflammatory status, and high blood pressure in T2DM.<br /> (Copyright © 2018 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.)

Details

Language :
English; Spanish; Castilian
ISSN :
2530-0180
Volume :
66
Issue :
2
Database :
MEDLINE
Journal :
Endocrinologia, diabetes y nutricion
Publication Type :
Academic Journal
Accession number :
30528492
Full Text :
https://doi.org/10.1016/j.endinu.2018.07.008