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Riluzole for treatment of men with methamphetamine dependence: A randomized, double-blind, placebo-controlled clinical trial.
- Source :
-
Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2019 Mar; Vol. 33 (3), pp. 305-315. Date of Electronic Publication: 2018 Dec 11. - Publication Year :
- 2019
-
Abstract
- Background: Riluzole is a glutamate regulator and effective in treatment of neuropsychiatric conditions.<br />Aims: We assessed riluzole for treatment of methamphetamine dependence.<br />Methods: In this randomized, double-blind, placebo-controlled clinical trial, male outpatients with methamphetamine dependence who were 18-65 years old received either 50 mg riluzole ( n=34) or placebo ( n=54) twice daily for 12 weeks. Patients were excluded in case of comorbid serious medical conditions or neurologic disorders, comorbid psychiatric disorders other than methamphetamine dependence requiring specific treatment interventions, simultaneous positive urine test result for substances of abuse other than methamphetamine, smoking >3 days per week, simultaneous consumption of medications which are contraindicated or have interaction with riluzole.<br />Results: Concerning primary outcomes, the cumulative mean number of attended weekly visits was higher in the riluzole arm compared with the placebo arm approaching a statistically significant difference (riluzole, median (range)=13.00 (2.00-13.00); placebo=4.00 (2.00-13.00); Mann-Whitney U=505.00, p-value=0.073), and the weekly measured rate of positive methamphetamine urine test results was significantly lower in the riluzole arm by the end of the study (riluzole=1 (5.00%), placebo=9 (45.00%), p-value=0.004). Patients in the riluzole arm experienced significantly greater improvement on all the craving, withdrawal, and depression measures regarding mean score changes from baseline to endpoint. No significant difference was detected between the two arms in terms of incidence of adverse events.<br />Conclusion: Future randomized clinical trials are needed to investigate proper dosing strategy in a more inclusive sample.
- Subjects :
- Adolescent
Adult
Aged
Craving drug effects
Depression epidemiology
Double-Blind Method
Excitatory Amino Acid Antagonists adverse effects
Excitatory Amino Acid Antagonists pharmacology
Humans
Male
Middle Aged
Riluzole adverse effects
Riluzole pharmacology
Treatment Outcome
Young Adult
Amphetamine-Related Disorders drug therapy
Excitatory Amino Acid Antagonists administration & dosage
Methamphetamine adverse effects
Riluzole administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1461-7285
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of psychopharmacology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 30526230
- Full Text :
- https://doi.org/10.1177/0269881118817166